Overall, 13% of patients reported treatment-related regret at 5 years. Among them, 6% of patients operated on, 11% undergoing radiation therapy and 7% undergoing active surveillance. There was no apparent association between regret and race. Future work should explore regret in other patient groups and use qualitative methods to substantiate best practices to reduce regret. Of the women who had RRM, all but one didn't regret the decision a year after the release of the test, but many struggled with body image, sexual interest and functioning, and self-esteem.
Sexual dysfunction, but not other patient-reported functional outcomes, was significantly associated with regret among patients who opted for surgery or radiation therapy. In the present study, the authors investigated whether patients expressed regret after undergoing HCT and the relationship between clinical outcomes and quality of life. Between 60 and 75% of affected people have physical abnormalities, such as short stature, abnormal skin pigmentation, radial ray defects (including malformation of the thumbs), abnormalities of the urinary tract, eyes, ears, heart, gastrointestinal system and central nervous system, hypogonadism and developmental delay. The encouraging news is that “given its relationship with expectations prior to treatment”, as the authors of the study pointed out, “treatment-related regret may change more if counseling is improved and patients' values and priorities are identified than functional outcomes and other factors that influence the survival experience of patients with prostate cancer.
BRCA1 variant carriers had a cumulative lifetime risk of 56% and 75% of developing breast cancer in the 10th and 90th percentiles of the PRS, respectively. Because of the bleeding, his doctor, heart surgeon Louis Samuels, took the unusual step of stopping taking blood thinners. Studies on the acceptance of genetic tests are difficult to compare because people may refuse the test at different times and with different levels of education and counseling prior to exams. After a difficult first week, Quinn recovered and quickly became the healthiest and most vigorous of the winners: an example of the heart, as Samuels said.
And the main reason for that regret seems to be the disconnect between patient expectations and outcomes. For carriers of the BRCA2 variant, the risk of ovarian cancer was 6% and 19% at age 80 for those in the 10th and 90th percentiles of the PRS, respectively. Comparisons between surgery and radiation therapy consistently showed greater regret for surgery, although they only differed significantly between people with a high-risk illness. Both the surgeon and the patient have described what happened when Quinn received the artificial heart as a profoundly religious experience.
